铁死亡相关机制、调控手段及相关疾病研究进展

曾杰, 陈玉宝, 徐晓玉

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (4) : 253-257.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (4) : 253-257. DOI: 10.11669/cpj.2017.04.001
综述

铁死亡相关机制、调控手段及相关疾病研究进展

  • 曾杰, 陈玉宝, 徐晓玉*
作者信息 +

Research Progress of Ferroptosis-Related Mechanisms, Regulation and Diseases

  • ZENG Jie, CHEN Yu-bao, XU Xiao-yu*
Author information +
文章历史 +

摘要

铁死亡(ferroptosis)是近年新发现的一种细胞死亡方式,其特征为细胞死亡过程中伴随着大量的铁离子累积和脂质过氧化。大量研究表明,该死亡方式与神经系统疾病、肿瘤、缺血再灌注损伤性疾病、肾损伤及铁代谢疾病等疾病密切相关,因此进行铁死亡的机制及其调控药物研究也显得尤为重要。笔者对铁死亡的相关机制、诱导剂和抑制剂以及其相关疾病进行总结分析,以期为研究铁死亡更深入机制以及从该机制出发研制有效的治疗药物提供参考。

Abstract

Recently, a new manner of cell death named ferroptosis is gradually accepted by researchers. It is characterized by cell death accompanied by a large accumulation of iron and lipid peroxidation. Numerous studies have shown that the manner of death are closely related to neurotoxicity, cancer, ischemia reperfusion injury, renal injury and iron metabolism related diseases,so the research of the mechanisms and regulative drugs for ferroptosis is particularly important. This paper reviewed the mechanisms, inducers, and inhibitors of ferroptosis and summarized the diseases related to ferroptosis, so that providing evidence for study the further mechanisms and development of new drugs for the ferroptosis-related diseases.

关键词

铁死亡 / 铁离子累积 / 脂质过氧化 / 诱导剂 / 抑制剂

Key words

ferroptosis / accumulation of iron / lipid peroxidation / inducer / inhibitor

引用本文

导出引用
曾杰, 陈玉宝, 徐晓玉. 铁死亡相关机制、调控手段及相关疾病研究进展[J]. 中国药学杂志, 2017, 52(4): 253-257 https://doi.org/10.11669/cpj.2017.04.001
ZENG Jie, CHEN Yu-bao, XU Xiao-yu. Research Progress of Ferroptosis-Related Mechanisms, Regulation and Diseases[J]. Chinese Pharmaceutical Journal, 2017, 52(4): 253-257 https://doi.org/10.11669/cpj.2017.04.001
中图分类号: R965   

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基金

国家科技重大新药创制专项(2014ZX09304-306-04);国家自然科学基金面上项目资助(81473549)
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